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KMID : 0358420070500010207
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Korean Journal of Obstetrics and Gynecology
2007 Volume.50 No. 1 p.207 ~ p.211
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A case of Lymphoepithelioma-Like carcinoma of the uterine cervix
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Kim Mi-Lyoung
You Hang-Jo
Yoon Eun-Suk
Sim Sung-Hyuk
Koo Bon-Sang
Joo Won-Duk
Cha Hee-Jung
Lee Hyun-Woo
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Abstract
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Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor with 0.7% of all primary cervical malignancies. It may grossly range from no visible cervical lesion to a large exophytic cervical mass and histologically similar neoplasms occur in the nasopharynx. It has been classified as a subtype of squamous cell carcinoma. But, after reviewing the literature, this tumor is a distinct carcinoma of the cervix that differs from squamous cell carcinoma. LELC is composed of undifferentiated cells surrounded by a marked inflammatory infiltrate, characterized by plasma cells and lymphocytes in the stroma. It may represent a better prognostic group than the more common squamous cell carcinoma of the cervix because of lack of lymph node metastasis. Typically affects a younger population of women, is more prevalent in noncaucasian population (especially, those of Asian descent). However, it is not clearly understood, Epstein-Barr virus play in the pathogenesis of cervical LELC while humam papilloma virus (HPV) is a risk factor for squamous cell carcinoma. The prognosis is good only by surgical treatment. Radiation therapy also appears to be effective in eradicating localized, low-stage disease (radiosensitive). The authors have experienced one case of LELC of the uterine cervix. We report a case with a brief review.
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KEYWORD
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Lymphoepithelioma-Like carcinoma, LELC, Uterine cervix
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